Asymmetric halo aldol reaction (AHA)

被引：24

作者：

Li, GG ^{[1
]}

Xu, X ^{[1
]}

Chen, DJ ^{[1
]}

Timmons, C ^{[1
]}

Carducci, MD ^{[1
]}

Headley, AD ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1021/ol027344+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric halo aldol reaction (AHA) using Evans oxazolidinones as chiral auxiliaries has been established for tandem I-C/C-C bond formations. The new asymmetric reaction provides a practical approach to a variety of halo aldols of a non-Evans type that cannot be easily synthesized by other methods. Excellent diastereoselectivity (>95%) and yields (80-93%) have been obtained for eight examples.

引用

页码：329 / 331

页数：3

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