The biogenesis and emerging roles of circular RNAs

被引：1384

作者：

Chen, Ling-Ling ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol,Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 04期

关键词：

EXON CIRCULARIZATION; XENOPUS-TROPICALIS; NONCODING RNA; IN-VIVO; INTRONS; SEQUENCE; REVEALS; MICRORNA; TRANSCRIPTION; INDUCTION;

D O I：

10.1038/nrm.2015.32

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels, recent findings have shed new light on their cell type-specific and tissue-specific expression and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs shape gene expression by titrating microRNAs, regulating transcription and interfering with splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.

引用

收藏

页码：205 / 211

页数：7

相关论文

共 63 条

[1] tRNA splicing [J].

Abelson, J ;

Trotta, CR ;

Li, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :12685-12688

[2] Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models [J].

Armakola, Maria ;

Higgins, Matthew J. ;

Figley, Matthew D. ;

Barmada, Sami J. ;

Scarborough, Emily A. ;

Diaz, Zamia ;

Fang, Xiaodong ;

Shorter, James ;

Krogan, Nevan J. ;

Finkbeiner, Steven ;

Farese, Robert V., Jr. ;

Gitler, Aaron D. .

NATURE GENETICS, 2012, 44 (12) :1302-1309

[3] circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[4] Correlation of circular RNA abundance with proliferation - exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues [J].

Bachmayr-Heyda, Anna ;

Reiner, Agnes T. ;

Auer, Katharina ;

Sukhbaatar, Nyamdelger ;

Aust, Stefanie ;

Bachleitner-Hofmann, Thomas ;

Mesteri, Ildiko ;

Grunt, Thomas W. ;

Zeillinger, Robert ;

Pils, Dietmar .

SCIENTIFIC REPORTS, 2015, 5 :8057

[5] The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva [J].

Bahn, Jae Hoon ;

Zhang, Qing ;

Li, Feng ;

Chan, Tak-Ming ;

Lin, Xianzhi ;

Kim, Yong ;

Wong, David T. W. ;

Xiao, Xinshu .

CLINICAL CHEMISTRY, 2015, 61 (01) :221-230

[6] Circular RNA biogenesis can proceed through an exon-containing lariat precursor [J].

Barrett, Steven P. ;

Wang, Peter L. ;

Salzman, Julia .

ELIFE, 2015, 4 :1-18

[7] Coupling mRNA processing with transcription in time and space [J].

Bentley, David L. .

NATURE REVIEWS GENETICS, 2014, 15 (03) :163-175

[8] Widespread intron retention in mammals functionally tunes transcriptomes [J].

Braunschweig, Ulrich ;

Barbosa-Morais, Nuno L. ;

Pan, Qun ;

Nachman, Emil N. ;

Alipanahi, Babak ;

Gonatopoulos-Pournatzis, Thomas ;

Frey, Brendan ;

Irimia, Manuel ;

Blencowe, Benjamin J. .

GENOME RESEARCH, 2014, 24 (11) :1774-1786

[9] Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA [J].

Broadbent, Kate M. ;

Broadbent, Jill C. ;

Ribacke, Ulf ;

Wirth, Dyann ;

Rinn, John L. ;

Sabeti, Pardis C. .

BMC GENOMICS, 2015, 16

[10] Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk [J].

Burd, Christin E. ;

Jeck, William R. ;

Liu, Yan ;

Sanoff, Hanna K. ;

Wang, Zefeng ;

Sharpless, Norman E. .

PLOS GENETICS, 2010, 6 (12) :1-15

← 1 2 3 4 5 6 7 →