A multidrug efflux transporter in Listeria monocytogenes

被引：79

作者：

Mata, MT ^{[1
]}

Baquero, F ^{[1
]}

Pérez-Díaz, JC ^{[1
]}

机构：

[1] Hosp Ramon y Cajal, Dept Microbiol, Natl Inst Hlth, E-28034 Madrid, Spain

来源：

FEMS MICROBIOLOGY LETTERS | 2000年 / 187卷 / 02期

关键词：

multidrug efflux pump; Listeria monocytogenes;

D O I：

10.1016/S0378-1097(00)00199-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A chromosomal gene (mdrL) was found in Listeria monocytogenes L028, showing a high degree of similarity with multidrug efflux transporters of the major facilitator superfamily (family 2). Atl allele-substituted mutant of this gene failed to pump out ethidium bromide and presented lower minimal inhibitory concentrations of macrolides, cefotaxime and heavy metals. This is the first multidrug efflux pump described in Listeria. (C) 2000 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.

引用

页码：185 / 188

页数：4

共 18 条

[1] RAPID EXTRACTION OF HIGH-PURITY CHROMOSOMAL DNA FROM SERRATIA-MARCESCENS [J].

ALONSO, R ;

NICHOLSON, PS ;

PITT, TL .

LETTERS IN APPLIED MICROBIOLOGY, 1993, 16 (02) :77-79

[2] Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters [J].

Baranova, NN ;

Danchin, A ;

Neyfakh, AA .

MOLECULAR MICROBIOLOGY, 1999, 31 (05) :1549-1559

[3] DUAL ROLES OF PLCA IN LISTERIA-MONOCYTOGENES PATHOGENESIS [J].

CAMILLI, A ;

TILNEY, LG ;

PORTNOY, DA .

MOLECULAR MICROBIOLOGY, 1993, 8 (01) :143-157

[4] Characterisation of a new operon encoding a Zur-like protein and an associated ABC zinc permease in Listeria monocytogenes [J].

Dalet, K ;

Gouin, E ;

Cenatiempo, Y ;

Cossart, P ;

Héchard, Y .

FEMS MICROBIOLOGY LETTERS, 1999, 174 (01) :111-116

[5] GENETIC-CHARACTERIZATION OF PLASMID-ENCODED MULTIPLE ANTIBIOTIC-RESISTANCE IN A STRAIN OF LISTERIA-MONOCYTOGENES CAUSING ENDOCARDITIS [J].

HADORN, K ;

HACHLER, H ;

SCHAFFNER, A ;

KAYSER, FH .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1993, 12 (12) :928-937

[6]

Huillet E, 1999, FEMS MICROBIOL LETT, V174, P265, DOI 10.1016/S0378-1097(99)00153-6

[7] EXPRESSION IN ESCHERICHIA-COLI AND SEQUENCE-ANALYSIS OF THE LISTERIOLYSIN-O DETERMINANT OF LISTERIA-MONOCYTOGENES [J].

MENGAUD, J ;

VICENTE, MF ;

CHENEVERT, J ;

PEREIRA, JM ;

GEOFFROY, C ;

GICQUELSANZEY, B ;

BAQUERO, F ;

PEREZDIAZ, JC ;

COSSART, P .

INFECTION AND IMMUNITY, 1988, 56 (04) :766-772

[8]

National Committee for Clinical Laboratory Standards (NCCLS), 1990, M7A2 NCCLS

[9] THE MULTIDRUG EFFLUX TRANSPORTER OF BACILLUS-SUBTILIS IS A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE STAPHYLOCOCCUS NORA PROTEIN [J].

NEYFAKH, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (02) :484-485

[10] EFFLUX-MEDIATED MULTIDRUG RESISTANCE IN BACILLUS-SUBTILIS - SIMILARITIES AND DISSIMILARITIES WITH THE MAMMALIAN SYSTEM [J].

NEYFAKH, AA ;

BIDNENKO, VE ;

CHEN, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4781-4785

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