Helicobacter pylori adhesion to carbohydrates

被引:46
作者
Aspholm, Marina
Kalia, Awdhesh
Ruhl, Stefan
Schedin, Staffan
Arnqvist, Anna
Linden, Sara
Sjostrom, Rolf
Gerhard, Markus
Semino-Mora, Cristina
Dubois, Andre
Unemo, Magnus
Danielsson, Dan
Teneberg, Susann
Lee, Woo-Kon
Berg, Douglas E.
Boren, Thomas
机构
来源
FUNCTIONAL GLYCOMICS | 2006年 / 417卷
关键词
D O I
10.1016/S0076-6879(06)17020-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.
引用
收藏
页码:293 / 339
页数:47
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