Expression of dopamine D2 receptor mRNA isoforms in the carotid body of rat, cat and rabbit

被引：10

作者：

Bairam, A ^{[1
]}

Khandjian, EW ^{[1
]}

机构：

[1] UNIV LAVAL, CHUQ, CTR RECH, UNITE RECH GENET HUMAINE & MOL, QUEBEC CITY, PQ, CANADA

来源：

BRAIN RESEARCH | 1997年 / 760卷 / 1-2期

关键词：

carotid body; dopamine; D2 receptor isoforms;

D O I：

10.1016/S0006-8993(97)00399-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the Reverse transcription-Polymerase chain reaction, we detected dopamine D2 receptor mRNA short and long isoforms in the adult carotid body of rats, cats, and rabbits. For these animals, the relative short/long ratios were 0.60, 0.65 and 0.57, respectively. Our results suggest that the variety of dopamine effects on carotid chemoreceptor activity, that has been related to species differences, may not be dependent on the expression levels of the dopamine D2 receptor mRNA isoforms in the studied species. (C) 1997 Elsevier Science B.V.

引用

页码：287 / 289

页数：3

共 16 条

[1] SPECIFIC INDUCTION OF A FUNCTIONAL ENDOGENOUS D2 SHORT DOPAMINE RECEPTOR IN GH4C1 CELLS [J].

ALLARD, S ;

LAPOINTE, S ;

FALARDEAU, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 193 (02) :801-807

[2] PRESENCE OF D1 RECEPTORS IN THE RABBIT CAROTID-BODY [J].

ALMARAZ, L ;

PEREZGARCIA, MT ;

GONZALEZ, C .

NEUROSCIENCE LETTERS, 1991, 132 (02) :259-262

[3] Expression of dopamine D2-receptor mRNA isoforms at the peripheral chemoreflex afferent pathway in developing rabbits [J].

Bairam, A ;

Dauphin, C ;

Rousseau, F ;

Khandjian, EW .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1996, 15 (03) :374-381

[4] DIFFERENCES IN THE LIGAND-BINDING PROPERTIES OF THE SHORT AND LONG VERSIONS OF THE D2 DOPAMINE RECEPTOR [J].

CASTRO, SW ;

STRANGE, PG .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (01) :372-375

[5] EXPRESSION OF D2-DOPAMINE RECEPTOR MESSENGER-RNA IN THE ARTERIAL CHEMORECEPTOR AFFERENT PATHWAY [J].

CZYZYKKRZESKA, MF ;

LAWSON, EE ;

MILLHORN, DE .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1992, 41 (1-2) :31-40

[6] EFFECTS OF PUTATIVE NEUROTRANSMITTERS OF THE CAROTID-BODY ON ITS OWN GLOMUS CELLS [J].

EYZAGUIRRE, C ;

MONTIBLOCH, L ;

WOODBURY, JW .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (01) :77-88

[7] Developmental expression of tyrosine hydroxylase, D-2-dopamine receptor and substance P genes in the carotid body of the rat [J].

Gauda, EB ;

Bamford, O ;

Gerfen, CR .

NEUROSCIENCE, 1996, 75 (03) :969-977

[8]

GAUDA EB, 1994, ADV EXP MED BIOL, V360, P317

[9] CAROTID-BODY CHEMORECEPTORS - FROM NATURAL STIMULI TO SENSORY DISCHARGES [J].

GONZALEZ, C ;

ALMARAZ, L ;

OBESO, A ;

RIGUAL, R .

PHYSIOLOGICAL REVIEWS, 1994, 74 (04) :829-898

[10]

LIU YF, 1992, J NEUROCHEM, V59, P2311

← 1 2 →