Tilt:: Major factor in sterols' ordering capability in membranes

被引：111

作者：

Aittoniemi, Jussi

Rog, Tomasz

Niemela, Perttu

Pasenkiewicz-Gierula, Marta

Karttunen, Mikko ^{[1
]}

Vattulainen, Ilpo

机构：

[1] Univ Western Ontario, Dept Appl Math, London, ON N6A 5B9, Canada

[2] Helsinki Univ Technol, Phys Lab, FIN-02150 Espoo, Finland

[3] Helsinki Univ Technol, Inst Phys, FIN-02150 Espoo, Finland

[4] Helsinki Univ Technol, Lab Computat Engn, Biophys & Stat Mech Grp, FIN-02150 Espoo, Finland

[5] Jagiellonian Univ, Dept Biophys, Krakow, Poland

[6] Tampere Univ Technol, Inst Phys, FIN-33101 Tampere, Finland

[7] Univ So Denmark, MEMPHYS, Ctr Biomembrane Phys, Odense, Denmark

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2006年 / 110卷 / 51期

关键词：

D O I：

10.1021/jp064931u

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Using extensive atomistic simulations, we show that there is a single experimentally accessible parameterthe sterol tiltthat can be used to determine a sterol's capability to induce order, and thus to promote, e.g., formation of lipid rafts. The observations also facilitate designing new effective sterols.

引用

收藏

页码：25562 / 25564

页数：3

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