Genetic association study of Endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura

被引：16

作者：

Tikka-Kleemola, P. ^{[1
,2
,3
]}

Kaunisto, M. A. ^{[1
,2
,3
,4
]}

Hamalainen, E. ^{[1
,2
]}

Todt, U. ^{[5
,6
,7
]}

Goebel, H. ^{[8
]}

Kaprio, J. ^{[3
,9
,10
]}

Kubisch, C. ^{[5
,6
,7
]}

Farkkila, M. ^{[11
]}

Palotie, A. ^{[1
,2
,3
,12
]}

Wessman, M. ^{[1
,2
,3
,4
]}

Kallela, M. ^{[11
]}

机构：

[1] Univ Helsinki, Res Program Mol Med, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Dept Clin Chem, FIN-00014 Helsinki, Finland

[3] Inst Mol Med, Helsinki, Finland

[4] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland

[5] Univ Cologne, Inst Human Genet, Cologne, Germany

[6] Univ Cologne, Inst Genet, D-5000 Cologne, Germany

[7] Univ Cologne, Ctr Mol Med Cologne, D-5000 Cologne, Germany

[8] Kiel Pain & Headache Ctr, Kiel, Germany

[9] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland

[10] Univ Helsinki, Cent Hosp, Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00014 Helsinki, Finland

[11] Univ Helsinki, Cent Hosp, Dept Neurol, FIN-00014 Helsinki, Finland

[12] MIT & Harvard, Broad Inst, Cambridge, MA USA

来源：

CEPHALALGIA | 2009年 / 29卷 / 11期

基金：

美国国家卫生研究院; 芬兰科学院;

关键词：

Endothelin-1; endothelin receptors A and B; migraine with aura; single nucleotide polymorphism; CORTICAL SPREADING DEPRESSION; LINKAGE; ACTIVATION;

D O I：

10.1111/j.1468-2982.2009.01855.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura (MA) susceptibility is not established yet. We studied the association between the MA end-diagnosis and three migraine trait components and 32 single nucleotide polymorphisms (SNPs) capturing the variation of endothelin genes in 850 Finnish migraine patients and 890 non-migrainous individuals. The SNPs showing evidence of association were further studied in 648 German migraine patients and 651 non-migrainous individuals. No significant association was detected. However, the homozygous minor genotype (5% in cases) of the EDNRA SNP rs2048894 showed nominal association with MA both in the Finnish sample (P = 0.015) and in the pooled sample [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12-2.32, P = 0.010] when adjusted for gender and sample origin. The trait age of onset < 20 years was also associated with rs2048894 (OR 1.69, 95% CI 1.13-2.54, P = 0.011) in the pooled sample. To confirm this finding studies on even larger samples are required.

引用

页码：1224 / 1231

页数：8

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