High-resolution structure of a β-peptide bundle

被引：171

作者：

Daniels, Douglas S.

Petersson, E. James

Qiu, Jade X.

Schepartz, Alanna ^{[1
]}

机构：

[1] Yale Univ, Dept Chem & Mol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 06期

关键词：

D O I：

10.1021/ja068678n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We recently reported that beta-peptides can form discrete hetero-oligomers in aqueous solution. Here we describe the structure of such an oligomer as determined by X-ray crystallography. The structure of Zwit-1F reveals a homo-octamer of two cupped "hands" composed of both parallel and antiparallel 3(14)-helices. The core of the assembly is composed entirely of solvent-excluded beta(3)-homoleucine residues. The Zwit-1F assembly shares many of the physical characteristics of natural proteins.

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页码：1532 / +

页数：3

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