Antimycobacterial activity of lipodepsipeptides produced by Pseudomonas syringae. pv syringae B359

被引：11

作者：

Buber, E

Stindl, A

Acan, NL

Kocagoz, T

Zocher, R

机构：

[1] Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Microbiol, TR-06100 Ankara, Turkey

[3] Tech Univ Berlin, Max Volmer Inst Biophys & Biol Chem, D-10587 Berlin, Germany

来源：

NATURAL PRODUCT LETTERS | 2002年 / 16卷 / 06期

关键词：

lipodepsipeptides; syringomycin E; syringopeptin; 22a; Pseudomonas syringae pv. syringae; mycobacterium; antimycobacterial activity;

D O I：

10.1080/10575630290034294

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some lipodepsipeptides produced by Pseudomonas syringae pv. syringae showed strong antimycobacterial activity towards Mycobacterium smegmatis. MIC values found were between 1.5-3.2 mug/ml, which is comparable to some primary drugs for tuberculosis. Among the lipodepsipeptides, Syringomycin E (SRE) appears to be the most potent antimycobacterial agent.

引用

收藏

页码：419 / 423

页数：5

相关论文

共 13 条

[1] SYRINGOPEPTINS, NEW PHYTOTOXIC LIPODEPSIPEPTIDES OF PSEUDOMONAS-SYRINGAE PV SYRINGAE [J].

BALLIO, A ;

BARRA, D ;

BOSSA, F ;

COLLINA, A ;

GRGURINA, I ;

MARINO, G ;

MONETI, G ;

PACI, M ;

PUCCI, P ;

SEGRE, A ;

SIMMACO, M .

FEBS LETTERS, 1991, 291 (01) :109-112

[2] New pyrrole derivatives as antimycobacterial agents analogs of BM212 [J].

Biava, M ;

Fioravanti, R ;

Porretta, GC ;

Deidda, D ;

Maullu, C ;

Pompei, R .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (20) :2983-2988

[3]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[4] CHEMICAL PROPERTIES OF SYRINGOMYCIN AND SYRINGOTOXIN - TOXIGENIC PEPTIDES PRODUCED BY PSEUDOMONAS-SYRINGAE [J].

GROSS, DC ;

DEVAY, JE ;

STADTMAN, FH .

JOURNAL OF APPLIED BACTERIOLOGY, 1977, 43 (03) :453-+

[5] Characterization of the syringomycin synthetase gene cluster - A link between prokaryotic and eukaryotic peptide synthetases [J].

Guenzi, E ;

Galli, G ;

Grgurina, I ;

Gross, DC ;

Grandi, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) :32857-32863

[6] Tuberculosis into the next century - Proceedings of a symposium held on 4 February 1995 at the Liverpool School of Tropical Medicine [J].

Hart, CA ;

Beeching, NJ ;

Duerden, BI .

JOURNAL OF MEDICAL MICROBIOLOGY, 1996, 44 (01) :1-+

[7]

Jackson CJ, 2000, FEMS MICROBIOL LETT, V192, P159, DOI 10.1111/j.1574-6968.2000.tb09375.x

[8] THE GLOBAL TUBERCULOSIS SITUATION AND THE NEW CONTROL STRATEGY OF THE WORLD-HEALTH-ORGANIZATION [J].

KOCHI, A .

TUBERCLE, 1991, 72 (01) :1-6

[9]

MURRAY PR, 1999, MANUAL CLIN MICROBIO, P1608

[10] THE STRUCTURE OF SYRINGOMYCIN-A1, SYRINGOMYCIN-E AND SYRINGOMYCIN-G [J].

SEGRE, A ;

BACHMANN, RC ;

BALLIO, A ;

BOSSA, F ;

GRGURINA, I ;

IACOBELLIS, NS ;

MARINO, G ;

PUCCI, P ;

SIMMACO, M ;

TAKEMOTO, JY .

FEBS LETTERS, 1989, 255 (01) :27-31