New pyrrole derivatives as antimycobacterial agents analogs of BM212

被引：88

作者：

Biava, M

Fioravanti, R

Porretta, GC

Deidda, D

Maullu, C

Pompei, R

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Cagliari, Fac Sci Matemat Fisiche Nat, Cattedra Microbiol Applicata, I-09124 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00510-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2-6 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2983 / 2988

页数：6

共 11 条

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