Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

被引：158

作者：

Deidda, D

Lampis, G

Fioravanti, R

Biava, M

Porretta, GC

Zanetti, S

Pompei, R

机构：

[1] Univ Cagliari, Cattedra Microbiol Applicata, Dipartimento Sci Med, I-09124 Cagliari, Italy

[2] Univ Rome La Sapienza, Dipartimento Studi Chim TSBA, Rome, Italy

[3] Univ Sassari, Ist Microbiol, I-07100 Sassari, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 11期

关键词：

D O I：

10.1128/AAC.42.11.3035

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl) methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

引用

页码：3035 / 3037

页数：3

共 22 条

[1] Reporter gene technology to assess activity of antimycobacterial agents in macrophages
Arain, TM
Resconi, AE
Singh, DC
Stover, CK
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (06) : 1542 - 1544
[2] INVITRO AND INVIVO ACTIVITIES OF THE NITROIMIDAZOLE CGI-17341 AGAINST MYCOBACTERIUM-TUBERCULOSIS
ASHTEKAR, DR
COSTAPERIRA, R
NAGRAJAN, K
VISHVANATHAN, N
BHATT, AD
RITTEL, W
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) : 183 - 186
[3] Biava M, 1997, MED CHEM RES, V7, P228
[4] BROWN BA, 1992, CLIN MICROBIOLOGY PR, V1
[5] STUDIES ON ANTICANDIDA AGENTS WITH A PYRROLE MOIETY - SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF SOME 3-AMINOMETHYL-1,5-DIARYL-2-METHYL-PYRROLE DERIVATIVES
CERRETO, F
VILLA, A
RETICO, A
SCALZO, M
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (07) : 701 - 708
[6] MYCOBACTERIAL DISEASE, IMMUNOSUPPRESSION, AND ACQUIRED IMMUNODEFICIENCY SYNDROME
COLLINS, FM
[J]. CLINICAL MICROBIOLOGY REVIEWS, 1989, 2 (04) : 360 - 377
[7] MULTIDRUG-RESISTANT TUBERCULOSIS
DOOLEY, SW
JARVIS, WR
MARTONE, WJ
SNIDER, DE
[J]. ANNALS OF INTERNAL MEDICINE, 1992, 117 (03) : 257 - 259
[8] Fioravanti R, 1996, FARMACO, V51, P643
[9] Fioravanti R, 1997, MED CHEM RES, V7, P87
[10] CLINICAL PRESENTATION AND OUTCOME OF PATIENTS WITH HIV-INFECTION AND TUBERCULOSIS CAUSED BY MULTIPLE-DRUG-RESISTANT BACILLI
FISCHL, MA
DAIKOS, GL
UTTAMCHANDANI, RB
POBLETE, RB
MORENO, JN
REYES, RR
BOOTA, AM
THOMPSON, LM
CLEARY, TJ
OLDHAM, SA
SALDANA, MJ
LAI, SH
[J]. ANNALS OF INTERNAL MEDICINE, 1992, 117 (03) : 184 - 190

← 1 2 3 →