Retinoic acid: An educational "vitamin elixir" for gut-seeking T cells

被引：46

作者：

Mora, JR

von Andrian, UH

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

IMMUNITY | 2004年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2004.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector cells with pronounced gut tropism. The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs (Iwata et al., 2004; this issue of Immunity).

引用

页码：458 / 460

页数：3