Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

被引：94

作者：

Jain, RK ^{[1
]}

Hamilton, AD ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 12期

关键词：

D O I：

10.1021/ol005871s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized, The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (K-d = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.

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页码：1721 / 1723

页数：3

相关论文

共 19 条

[11] COMPLEX-FORMATION BETWEEN CYTOCHROME-C AND CYTOCHROME-C PEROXIDASE - KINETIC STUDIES [J].

NICHOLLS, P ;

MOCHAN, E .

BIOCHEMICAL JOURNAL, 1971, 121 (01) :55-&

[12] Novel approaches to molecular recognition using porphyrins [J].

Ogoshi, H ;

Mizutani, T .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (06) :736-739

[13] Protein surface recognition by synthetic receptors:: A route to novel submicromolar inhibitors for α-chymotrypsin [J].

Park, HS ;

Lin, Q ;

Hamilton, AD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (01) :8-13

[14] Porphyrin and phthalocyanine antiscrapie compounds [J].

Priola, SA ;

Raines, A ;

Caughey, WS .

SCIENCE, 2000, 287 (5457) :1503-1506

[15] Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase [J].

Regan, J ;

McGarry, D ;

Bruno, J ;

Green, D ;

Newman, J ;

Hsu, CY ;

Kline, J ;

Barton, J ;

Travis, J ;

Choi, YM ;

Volz, F ;

Pauls, H ;

Harrison, R ;

Zilberstein, A ;

BenSasson, SA ;

Chang, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (21) :3408-3422

[16]

Scott R.A., 1996, CYTOCHROME C MULTIDI

[17] Protein-protein interactions: Interface structure, binding thermodynamics, and mutational analysis [J].

Stites, WE .

CHEMICAL REVIEWS, 1997, 97 (05) :1233-1250

[18]

WILCOX CS, 1990, FRONTIERS SUPRAMOLEC, P123

[19] PHOTOINDUCED ELECTRON-TRANSFER IN SELF-ASSOCIATED COMPLEXES OF SEVERAL UROPORPHYRINS AND CYTOCHROME-C [J].

ZHOU, JS ;

GRANADA, ESV ;

LEONTIS, NB ;

RODGERS, MAJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (13) :5074-5080