Circadian rhythm of plasma sodium is disrupted in spontaneously hypertensive rats fed a high-NaCl diet

被引：40

作者：

Fang, ZW ^{[1
]}

Carlson, SH ^{[1
]}

Peng, N ^{[1
]}

Wyss, JM ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2000年 / 278卷 / 06期

关键词：

salt; sympathetic activity; mean arterial pressure;

D O I：

10.1152/ajpregu.2000.278.6.R1490

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

High-NaCl diets elevate arterial pressure in NaCl-sensitive individuals, and increases in plasma sodium may trigger this effect. The present study tests the hypotheses that 1) plasma sodium displays a circadian rhythm in rats, 2) the plasma sodium rhythm is disturbed in spontaneously hypertensive rats (SHR), and 3) excess dietary NaCl elevates plasma sodium concentration in SHR. The results demonstrate that plasma sodium has a circadian rhythm that is inversely related to the circadian rhythm of arterial pressure. Although the plasma sodium rhythms of SHR and control rats are nearly identical, the plasma sodium concentrations are significantly higher in SHR throughout the 24-h cycle. Maintenance on a high-NaCl diet increases plasma sodium concentration similarly in both SHR and control rats, but it blunts the plasma sodium rhythm only in SHR. These results demonstrate that in rats, plasma sodium has a circadian rhythm and that high-NaCl diets increase plasma sodium concentration.

引用

页码：R1490 / R1495

页数：6