Natural product guided compound library development

被引：62

作者：

Breinbauer, R

Manger, M

Scheck, M

Waldmann, H

机构：

[1] Max Planck Inst Mol Physiol, Dept Chem Biol, D-44227 Dortmund, Germany

[2] Univ Dortmund, Fachbereich 3, D-44221 Dortmund, Germany

来源：

CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 23期

关键词：

combinatorial chemistry; drug discovery; lead optimisation; natural products; organic synthesis; protein domains; solid phase synthesis;

D O I：

10.2174/0929867023368773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products are biologically validated starting points for the design of combinatorial libraries, as they have a proven record of biological relevance. This special role of natural products in medicinal chemistry and chemical biology can be interpreted in the light of new insights about the domain architecture of proteins gained by structural biology and bioinformatics. In order to fulfil the specific requirements of the individual binding pocket within a domain family it is necessary to optimise the natural product structure by chemical variation. Solid-phase chemistry is becoming an efficient tool for this optimisation process, and recent advances in this field are highlighted in this review article.

引用

页码：2129 / 2145

页数：17

共 90 条

[81] Recognizing molecules with drug-like properties
Walters, WP
Murcko, A
Murcko, MA
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (04) : 384 - 387
[82] Watson C, 1999, ANGEW CHEM INT EDIT, V38, P1903, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1903::AID-ANIE1903>3.0.CO
[83] 2-Z
[84] Wess G, 2001, ANGEW CHEM INT EDIT, V40, P3341, DOI 10.1002/1521-3773(20010917)40:18<3341::AID-ANIE3341>3.0.CO
[85] 2-D
[86] Synthesis of natural-product-based compound libraries
Wessjohann, LA
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (03) : 303 - 309
[87] Estimating the number of protein folds and families from complete genome data
Wolf, YI
Grishin, NV
Koonin, EV
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 299 (04) : 897 - 905
[88] Combinatorial library approach for the identification of synthetic receptors targeting vancomycin-resistant bacteria
Xu, R
Greiveldinger, G
Marenus, LE
Cooper, A
Ellman, JA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (20) : 4898 - 4899
[89] Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro
Zava, DT
Duwe, G
[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (01): : 31 - 40
[90] Zhang MQ, 1997, CURR MED CHEM, V4, P67

← 1 2 3 4 5 6 7 8 9 →