Multifactorial aspects of antimicrobial activity of propolis

被引：124

作者：

Scazzocchio, F.

D'Auria, F. D.

Alessandrini, D.

Pantanella, F.

机构：

[1] Univ Roma La Sapienza, Fac Farm, Dipartimento Sci Sanita Pubbl, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Fac Med, Dipartimento Sci Sanita Pubbl, I-00185 Rome, Italy

来源：

MICROBIOLOGICAL RESEARCH | 2006年 / 161卷 / 04期

关键词：

antimicrobial activity; propolis; synergistic effect; lipase; coagulase; biofilm;

D O I：

10.1016/j.micres.2005.12.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the antibacterial activity of sub-inhibitory concentrations of ethanolic extract of propolis (EEP), and its effect on the antibacterial activity of some antibiotics. Some clinically isolated Gram-positive strains were used. Moreover, sub-inhibitory concentrations of EEP were used to value its action on some important virulence factors like lipase and coagulase enzymes, and on biofilm formation in Staphylococcus aureus. Our results indicated that EEP had a significant antimicrobial activity towards all tested clinical strains. Adding EEP to antibacterial tested drugs, it drastically increased the antimicrobial effect of ampicillin, gentamycin and streptomycin, moderately the one of chloramphenicol, ceftriaxon and vancomycin, while there was no effect with erithromycin. Moreover, our results pointed out an inhibitory action of EEP on tipase activity of 18 Staphytococcus spp. strains and an inhibitory effect on coagulase of 11 S. aureus tested strains. The same EEP concentrations showed a negative interaction with adhesion and consequent biofilm formation in S. aureus ATCC 6538P. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：327 / 333

页数：7

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