Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype

被引:273
作者
Mogil, JS
Chesler, EJ
Wilson, SG
Juraska, JM
Sternberg, WF
机构
[1] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA
[2] Univ Illinois, Program Neurosci, Champaign, IL 61820 USA
[3] Haverford Coll, Dept Psychol, Haverford, PA 19041 USA
关键词
analgesia; antinociception; genetics; mice; morphine; nociception; opioid; outbred strains; pain; rats; review; sex differences;
D O I
10.1016/S0149-7634(00)00015-4
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
It has been appreciated for some time that the sexes can differ in their sensitivity to pain and its inhibition. Both the human and rodent literatures remain quite contentious, with many investigators failing to observe sex differences that others document clearly. Recent data from our laboratory have pointed to an interaction between sex and genotype in rodents, such that sex differences are observed in some strains but not others. However, these studies employed inbred mouse strains and are thus not directly relevant to existing data. We presently examined whether the observation of statistically significant sex differences in nociception and morphine antinociception might depend on the particular outbred rodent population chosen for study. Rats of both sexes and three common outbred strains were obtained from three suppliers (Long Evans, Simonsen; Sprague Dawley, Harlan; Wistar Kyoto, Taconic) and tested for nociceptive sensitivity on the 49 degrees C tail-withdrawal assay, and antinociception following morphine (1-10 mg/kg, i.p.). In further studies, three outbred populations of mice (CD-1, Harlan; Swiss Webster, Harlan; Swiss Webster, Simonsen) were bred in our vivarium for several generations and tested for tail-withdrawal sensitivity and morphine antinociception (1-20 mg/kg, i.p.). We observed all possible sex comparison patterns for these two traits in different rodent populations: male > female, female > male, and no significant difference. In a separate study in which the estrous cycle was tracked in female mice, we found evidence for an interaction between genotype and estrous phase relevant to morphine antinociception. However, estrous cyclicity did not explain the observed sex differences. These data are discussed with respect to the existing sex difference and pain literature, and also as they pertain to future investigations of these phenomena. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:375 / 389
页数:15
相关论文
共 101 条
[1]   SEX-DIFFERENCES AND THE EFFECT OF GONADECTOMY ON MORPHINE-INDUCED ANTINOCICEPTION AND DEPENDENCE IN RATS AND MICE [J].
ALI, BH ;
SHARIF, SI ;
ELKADI, A .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1995, 22 (05) :342-344
[2]   SEX-RELATED EFFECTS ON BEHAVIOR AND BETA-ENDORPHIN OF DIFFERENT INTENSITIES OF FORMALIN PAIN IN RATS [J].
ALOISI, AM ;
SACERDOTE, P ;
ALBONETTI, ME ;
CARLI, G .
BRAIN RESEARCH, 1995, 699 (02) :242-249
[3]   SEX-DIFFERENCES IN THE BEHAVIORAL-RESPONSE TO PERSISTENT PAIN IN RATS [J].
ALOISI, AM ;
ALBONETTI, ME ;
CARLI, G .
NEUROSCIENCE LETTERS, 1994, 179 (1-2) :79-82
[4]   SEX-DEPENDENT EFFECTS OF RESTRAINT ON NOCICEPTION AND PITUITARY-ADRENAL HORMONES IN THE RAT [J].
ALOISI, AM ;
STEENBERGEN, HL ;
VANDEPOLL, NE ;
FARABOLLINI, F .
PHYSIOLOGY & BEHAVIOR, 1994, 55 (05) :789-793
[5]  
Aloisi AM, 1996, NEUROSCIENCE, V74, P1019, DOI 10.1016/S0306-4522(96)00232-1
[6]  
[Anonymous], APS J
[7]   POST-NATAL MORPHINE DIFFERENTIALLY AFFECTS OPIATE AND STRESS ANALGESIA IN ADULT-RATS [J].
ARJUNE, D ;
BODNAR, RJ .
PSYCHOPHARMACOLOGY, 1989, 98 (04) :512-517
[8]   SEX-RELATED DIFFERENCES IN THE EFFECTS OF MORPHINE AND STRESS ON VISCERAL PAIN [J].
BAAMONDE, AI ;
HIDALGO, A ;
ANDRESTRELLES, F .
NEUROPHARMACOLOGY, 1989, 28 (09) :967-970
[9]  
BANARJEE P, 1983, EUR J PHARMACOL, V96, P291
[10]  
Bartok RE, 1997, J PHARMACOL EXP THER, V282, P769