Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients

被引：58

作者：

Al-Kafaji, Ghada ^{[1
]}

Al-Mahroos, Ghazi ^{[2
]}

Al-Muhtaresh, Haifa Abdulla ^{[1
]}

Sabry, Mohamed Abdalla ^{[1
]}

Razzak, Rima Abdul ^{[1
]}

Salem, Abdel Halim ^{[1
]}

机构：

[1] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain

[2] Salmaniya Med Complex, Diabet & Endocrinol Clin, Manama, Bahrain

来源：

BIOMARKERS | 2017年 / 22卷 / 3-4期

关键词：

Biomarker; circulating miR-126; coronary artery disease; microRNAs; type; 2; diabetes; PERIPHERAL-BLOOD; CARDIOVASCULAR RISK; GLYCOSYLATED HEMOGLOBIN; DIAGNOSTIC BIOMARKERS; GLYCATED HEMOGLOBIN; PLASMA MICRORNAS; MIR-126; CANCER; EXPRESSION; COMPLICATIONS;

D O I：

10.1080/1354750X.2016.1204004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.

引用

页码：268 / 278

页数：11

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