Periodontal disease: bacterial virulence factors, host response and impact on systemic health

被引：76

作者：

Graves, DT ^{[1
]}

Jiang, YL ^{[1
]}

Genco, C ^{[1
]}

机构：

[1] Boston Univ, Sch Dent Med, Dept Periodontol & Oral Biol, Boston, MA USA

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2000年 / 13卷 / 03期

关键词：

D O I：

10.1097/00001432-200006000-00005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Teeth are coated with a biofilm that contains periodontal pathogens. Pathogens express virulence factors which enable them to invade and replicate within epithelial cells and to invade the underlying connective tissue, This stimulates production of prostaglandins and cytokines that induce tissue loss. In addition, these bacteria have the potential to modulate the course of systemic diseases such as atherosclerosis and to contribute to low birthweight and preterm labor. Curr Opin Infect Dis 13:227-232. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：227 / 232

页数：6

共 72 条

[1] Association between extent of periodontal attachment loss and self-reported history of heart attack: An analysis of NHANES III data [J].

Arbes, SJ ;

Slade, GD ;

Beck, JD .

JOURNAL OF DENTAL RESEARCH, 1999, 78 (12) :1777-1782

[2]

Assuma R, 1998, J IMMUNOL, V160, P403

[3] Smoking and crevicular fluid levels of IL-6 and TNF-α in periodontal disease [J].

Boström, L ;

Linder, LE ;

Bergström, J .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1999, 26 (06) :352-357

[4] Clinical expression of TNF-α in smoking-associated periodontal disease [J].

Bostrom, L ;

Linder, LE ;

Bergstrom, J .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1998, 25 (10) :767-773

[5] Multiple infections in carotid atherosclerotic plaques [J].

Chiu, B .

AMERICAN HEART JOURNAL, 1999, 138 (05) :S534-S536

[6] EFFECTS OF ESCHERICHIA-COLI AND PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE ON PREGNANCY OUTCOME IN THE GOLDEN-HAMSTER [J].

COLLINS, JG ;

SMITH, MA ;

ARNOLD, RR ;

OFFENBACHER, S .

INFECTION AND IMMUNITY, 1994, 62 (10) :4652-4655

[7]

Cutler Christopher W., 1995, Trends in Microbiology, V3, P45, DOI 10.1016/S0966-842X(00)88874-5

[8] Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis [J].

Darveau, RP ;

Belton, CM ;

Reife, RA ;

Lamont, RJ .

INFECTION AND IMMUNITY, 1998, 66 (04) :1660-1665

[9] ABILITY OF BACTERIA ASSOCIATED WITH CHRONIC INFLAMMATORY DISEASE, TO STIMULATE E-SELECTIN EXPRESSION AND PROMOTE NEUTROPHIL ADHESION [J].

DARVEAU, RP ;

CUNNINGHAM, MD ;

BAILEY, T ;

SEACHORD, C ;

RATCLIFFE, K ;

BAINBRIDGE, B ;

DIETSCH, M ;

PAGE, RC ;

ARUFFO, A .

INFECTION AND IMMUNITY, 1995, 63 (04) :1311-1317

[10] The microbial challenge in periodontitis [J].

Darveau, RP ;

Tanner, A ;

Page, RC .

PERIODONTOLOGY 2000, 1997, 14 :12-32

← 1 2 3 4 5 6 7 8 →