Periodontal disease: bacterial virulence factors, host response and impact on systemic health

被引：76

作者：

Graves, DT ^{[1
]}

Jiang, YL ^{[1
]}

Genco, C ^{[1
]}

机构：

[1] Boston Univ, Sch Dent Med, Dept Periodontol & Oral Biol, Boston, MA USA

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2000年 / 13卷 / 03期

关键词：

D O I：

10.1097/00001432-200006000-00005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Teeth are coated with a biofilm that contains periodontal pathogens. Pathogens express virulence factors which enable them to invade and replicate within epithelial cells and to invade the underlying connective tissue, This stimulates production of prostaglandins and cytokines that induce tissue loss. In addition, these bacteria have the potential to modulate the course of systemic diseases such as atherosclerosis and to contribute to low birthweight and preterm labor. Curr Opin Infect Dis 13:227-232. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：227 / 232

页数：6

共 72 条

[51] Antagonistic effect of synthetic peptides corresponding to the binding regions within fimbrial subunit protein from Porphyromonas gingivalis to human gingival fibroblasts [J].

Ogawa, T ;

Ogo, H ;

Kinoshita, A .

VACCINE, 1997, 15 (02) :230-236

[52] ASSOCIATION OF TUMOR-NECROSIS-FACTOR (TNF) AND CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ALLELES WITH THE SECRETION OF TNF-ALPHA AND TNF-BETA BY HUMAN MONONUCLEAR-CELLS - A POSSIBLE LINK TO INSULIN-DEPENDENT DIABETES-MELLITUS [J].

POCIOT, F ;

BRIANT, L ;

JONGENEEL, CV ;

MOLVIG, J ;

WORSAAE, H ;

ABBAL, M ;

THOMSEN, M ;

NERUP, J ;

CAMBONTHOMSEN, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (01) :224-231

[53] PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE IS POORLY RECOGNIZED BY MOLECULAR-COMPONENTS OF INNATE HOST-DEFENSE IN A MOUSE MODEL OF EARLY INFLAMMATION [J].

REIFE, RA ;

SHAPIRO, RA ;

BAMBER, BA ;

BERRY, KK ;

MICK, GE ;

DARVEAU, RP .

INFECTION AND IMMUNITY, 1995, 63 (12) :4686-4694

[54] Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients [J].

Salvi, GE ;

Yalda, B ;

Collins, JG ;

Jones, BH ;

Smith, FW ;

Arnold, RR ;

Offenbacher, S .

JOURNAL OF PERIODONTOLOGY, 1997, 68 (02) :127-135

[55]

SCHIFFERLE RE, 1989, J IMMUNOL, V143, P3035

[56] PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE STIMULATION OF HUMAN MONOCYTES - DEPENDENCE ON SERUM AND CD14-RECEPTOR [J].

SHAPIRA, L ;

TAKASHIBA, S ;

AMAR, S ;

VANDYKE, TE .

ORAL MICROBIOLOGY AND IMMUNOLOGY, 1994, 9 (02) :112-117

[57] BACTERIAL PENETRATION OF GINGIVA IN THE ADULT BEAGLE DOG WITH PERIODONTITIS [J].

SILVERSTEIN, LH ;

SCHUSTER, GS ;

GARNICK, JJ ;

SINGH, B .

JOURNAL OF PERIODONTOLOGY, 1990, 61 (01) :35-41

[58] Does the mouth put the heart at risk? [J].

Slavkin, HC .

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1999, 130 (01) :109-113

[59] Ecological considerations in the treatment of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis periodontal infections [J].

Socransky, SS ;

Haffajee, AD ;

Ximenez-Fyvie, LA ;

Feres, M ;

Mager, D .

PERIODONTOLOGY 2000, 1999, 20 :341-362

[60] THE BACTERIAL ETIOLOGY OF DESTRUCTIVE PERIODONTAL-DISEASE - CURRENT CONCEPTS [J].

SOCRANSKY, SS ;

HAFFAJEE, AD .

JOURNAL OF PERIODONTOLOGY, 1992, 63 (04) :322-331

← 1 2 3 4 5 6 7 8 →