An epiisopicropodophyllin aza analogue via palladium-catalyzed pseudo-domino cyclization

被引：106

作者：

Poli, G ^{[1
]}

Giambastiani, G ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR 7611, F-75252 Paris 05, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 26期

关键词：

D O I：

10.1021/jo026068+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation.

引用

页码：9456 / 9459

页数：4

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