Effects of hypothermia on energy metabolism in rat and Richardson's ground squirrel hearts

被引：11

作者：

Belke, DD

Wang, LCH

Lopaschuk, GD

机构：

[1] UNIV ALBERTA, HERITAGE MED RES CTR 423, CARDIOVASC DIS RES GRP, DEPT PHARMACOL, EDMONTON, AB T6G 2S2, CANADA

[2] UNIV ALBERTA, DEPT PEDIAT, EDMONTON, AB T6G 2S2, CANADA

[3] UNIV ALBERTA, DEPT BIOL SCI, EDMONTON, AB T6G 2S2, CANADA

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 1997年 / 82卷 / 04期

关键词：

glucose oxidation; glycolysis; fatty acid oxidation; cardiac efficiency;

D O I：

10.1152/jappl.1997.82.4.1210

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Glycolysis, glucose oxidation, palmitate oxidation, and cardiac function were measured in isolated working hearts from ground squirrels and rats subjected to a hypothermia-rewarming protocol. Hearts were perfused initially for 30 min at 37 degrees C, followed by 2 h of hypothermic perfusion at 15 degrees C, after which hearts were rewarmed to 37 degrees C and further perfused for 30 min. Functional recovery in ground squirrel hearts was greater than in rat hearts after rewarming. Hypothermia-rewarming had a similar general effect on the various metabolic pathways in both species. Despite these similarities, total energy substrate metabolic rates were greater in rat than ground squirrel hearts during hypothermia despite a lower level of work being performed by the rat hearts, indicating that rat hearts are less efficient than ground squirrel hearts during hypothermia. After rewarming, energy substrate metabolism recovered completely in both species, although cardiac work remained depressed in rat hearts. The difference in functional recovery between rat and ground squirrel hearts after rewarming cannot be explained by general differences in energy substrate metabolism during hypothermia or after rewarming.

引用

页码：1210 / 1218

页数：9

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