Lens induction in vertebrates: Variations on a conserved theme of signaling events

被引：51

作者：

Donner, Amy L.

Lachke, Salil A.

Maas, Richard L.

机构：

[1] Brigham & Womens Hosp, Div Genet, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 06期

关键词：

lens; placode; Six1; Pax6; Sox2;

D O I：

10.1016/j.semcdb.2006.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review provides an overview of our current understanding of signaling mechanisms involved in lens induction, which are presented in context of the major stages of lens induction (competence, bias, inhibition and specification). Although the process of lens induction is generally well conserved, we highlight aspects of induction that vary among species. Finally, this review identifies future challenges in forming an integrated network of signaling pathways involved in lens induction. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：676 / 685

页数：10

共 79 条

[11] Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein [J].