TNP-470 combined with nicardipine suppresses in vivo growth of PC-3, a human prostate cancer cell line

被引：6

作者：

Arisawa, C ^{[1
]}

Kageyama, Y ^{[1
]}

Kawakami, S ^{[1
]}

Kihara, K ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Urol & Reprod Med, Bunkyo Ku, Tokyo 1138519, Japan

来源：

UROLOGIC ONCOLOGY | 2002年 / 7卷 / 06期

关键词：

angiogenesis; inhibitor; prostate; neoplasm;

D O I：

10.1016/S1078-1439(02)00195-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined effects of TNP-470 with or without nicardipine on in vivo or in vitro growth of a hormone-independent human prostate carcinoma cell line, PC-3. TNP-470 (30 mg/kg, daily) or nicardipine (25 mug/kg, daily) alone had little effects on in vivo growth of PC-3 cells in Dude mice, whereas simultaneous administration of both agents significantly inhibited the growth of the xenografts. In vitro proliferarion of PC-3 was not affected by TNP-470 and/or nicardipin. Combination of TNP-470 and nicardipine seems beneficial in the treatment of hormone-refractory prostate cancer. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：229 / 234

页数：6

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