The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

被引：245

作者：

Brooks, Tracy A.

Hurley, Laurence H. ^{[1
]}

机构：

[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

NUCLEASE HYPERSENSITIVE ELEMENT; I-MOTIF STRUCTURES; G-QUADRUPLEX DNA; ONCOGENE C-MYC; SINGLE-STRANDED-DNA; HUMAN KRAS PROMOTER; B-CELL LYMPHOMA; GENE-EXPRESSION; HUMAN GENOME; BINDING-PROTEIN;

D O I：

10.1038/nrc2733

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MYC is deregulated in most tumour types, but an effective means to selectively target its aberrant expression is not yet available. Supercoiling that is induced by transcription has been demonstrated to have dynamic effects on DNA in the MYC promoter element: it converts duplex DNA to non-duplex DNA structures, even at considerable distances from the transcriptional start site. These non-duplex DNA structures, which control both turning on and off of transcription and the rate of transcription firing, are amenable to small-molecule targeting. This dynamic system provides a unique opportunity for the treatment of tumours in which MYC is an important oncogene.

引用

收藏

页码：849 / 861

页数：13

相关论文

共 135 条

[81] Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo [J].

Michelotti, GA ;

Michelotti, EF ;

Pullner, A ;

Duncan, RC ;

Eick, D ;

Levens, D .

MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (06) :2656-2669

[82] c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry [J].

Morrish, F. ;

Isern, N. ;

Sadilek, M. ;

Jeffrey, M. ;

Hockenbery, D. M. .

ONCOGENE, 2009, 28 (27) :2485-2491

[83] Identification of Functional Networks of Estrogen- and c-Myc-Responsive Genes and Their Relationship to Response to Tamoxifen Therapy in Breast Cancer [J].

Musgrove, Elizabeth A. ;

Sergio, C. Marcelo ;

Loi, Sherene ;

Inman, Claire K. ;

Anderson, Luke R. ;

Alles, M. Chehani ;

Pinese, Mark ;

Caldon, C. Elizabeth ;

Schuette, Judith ;

Gardiner-Garden, Margaret ;

Ormandy, Christopher J. ;

McArthur, Grant ;

Butt, Alison J. ;

Sutherland, Robert L. .

PLOS ONE, 2008, 3 (08)

[84] Abnormal expression of apoptosis-related genes in haematological malignancies:: overexpression of MYC is poor prognostic sign in mantle cell lymphoma [J].

Nagy, B ;

Lundán, T ;

Larramendy, ML ;

Aalto, Y ;

Zhu, Y ;

Niini, T ;

Edgren, H ;

Ferrer, A ;

Vilpo, J ;

Elonen, E ;

Vettenranta, K ;

Franssila, K ;

Knuutila, S .

BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (03) :434-441

[85] MYC oncogenes and human neoplastic disease [J].

Nesbit, CE ;

Tersak, JM ;

Prochownik, EV .

ONCOGENE, 1999, 18 (19) :3004-3016

[86] Myc pathways provoking cell suicide and cancer [J].

Nilsson, JA ;

Cleveland, JL .

ONCOGENE, 2003, 22 (56) :9007-9021

[87] The myc oncogene:: (M)under-bar-arvelousl(Y)under-bar (C)under-bar-omplex [J].

Oster, SK ;

Ho, CSW ;

Soucie, EL ;

Penn, LZ .

ADVANCES IN CANCER RESEARCH, VOL 84, 2002, 84 :81-154

[88] Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives [J].

Ou, Tian-Miao ;

Lu, Yu-Jing ;

Zhang, Chi ;

Huang, Zhi-Shu ;

Wang, Xiao-Dong ;

Tan, Jia-Heng ;

Chen, Yuan ;

Ma, Dik-Lung ;

Wong, Kwok-Yin ;

Tang, Johnny Cheuk-On ;

Chan, Albert Sun-Chi ;

Gu, Lian-Quan .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (07) :1465-1474

[89] Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands [J].

Palumbo, SunMi L. ;

Ebbinghaus, Scot W. ;

Hurley, Laurence H. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (31) :10878-10891

[90] Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription [J].

Paramasivam, Manikandan ;

Membrino, Alexandro ;

Cogoi, Susanna ;

Fukuda, Hirokazu ;

Nakagama, Hitoshi ;

Xodo, Luigi E. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (09) :2841-2853

← 4 5 6 7 8 9 10 11 12 13 →