FoxOs in tumor suppression and stem cell maintenance

被引：77

作者：

Arden, Karen C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

CELL | 2007年 / 128卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.01.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The FoxO transcription factors have been implicated in many processes including tumor suppression and cell death. In this issue, two groups now report on mice that conditionally lack the three predominant FoxO transcription factors. Tothova et al. (2007) demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic stem cells, and Paik et al. (2007) show that FoxOs suppress the formation of hemangiomas and lymphomas in mice.

引用

页码：235 / 237

页数：3

共 9 条

[1] Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer [J].

Arden, Karen C. .

EXPERIMENTAL GERONTOLOGY, 2006, 41 (08) :709-717

[2] Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a [J].

Castrillon, DH ;

Miao, LL ;

Kollipara, R ;

Horner, JW ;

DePinho, RA .

SCIENCE, 2003, 301 (5630) :215-218

[3] FOXO transcription factors at the interface between longevity and tumor suppression [J].

Greer, EL ;

Brunet, A .

ONCOGENE, 2005, 24 (50) :7410-7425

[4] Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification [J].

Hosaka, T ;

Biggs, WH ;

Tieu, D ;

Boyer, AD ;

Varki, NM ;

Cavenee, WK ;

Arden, KC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2975-2980

[5] A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells [J].

Kau, TR ;

Schroeder, F ;

Ramaswamy, S ;

Wojciechowski, CL ;

Zhao, JJ ;

Roberts, TM ;

Clardy, J ;

Sellers, WR ;

Silver, PA .

CANCER CELL, 2003, 4 (06) :463-476

[6] Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress [J].

Kops, GJPL ;

Dansen, TB ;

Polderman, PE ;

Saarloos, I ;

Wirtz, KWA ;

Coffer, PJ ;

Huang, TT ;

Bos, JL ;

Medema, RH ;

Burgering, BMT .

NATURE, 2002, 419 (6904) :316-321

[7]

PAIK JH, 2007, CELL

[8] The psammaplysenes, specific inhibitors of FOXO1a nuclear export [J].

Schroeder, FC ;

Kau, TR ;

Silver, PA ;

Clardy, J .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (04) :574-576

[9]

TOTHOVA Z, 2007, CELL

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