Red Blood Cells for Glucose-Responsive Insulin Delivery

被引：142

作者：

Wang, Chao ^{[1
,2
,3
,4
]}

Ye, Yanqi ^{[1
,2
,3
,4
]}

Sun, Wujin ^{[1
,2
,3
,4
]}

Yu, Jicheng ^{[1
,2
,3
,4
]}

Wang, Jingqiang ^{[1
,2
,3
,4
]}

Lawrence, David S. ^{[5
,6
,7
]}

Buse, John B. ^{[8
]}

Gu, Zhen ^{[1
,2
,3
,4
,8
]}

机构：

[1] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[2] North Carolina State Univ, Raleigh, NC 27695 USA

[3] Univ N Carolina, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[6] Univ N Carolina, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA

[7] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[8] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 18期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

CATIONIC COPOLYMER HYDROGELS; DRUG-DELIVERY; IN-VIVO; NANOPARTICLES; THERAPY; ERYTHROCYTES; TRANSPORTERS; PATCHES; SYSTEMS; RELEASE;

D O I：

10.1002/adma.201606617

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Glucose-responsive delivery of insulin mimicking the function of pancreatic beta-cells to achieve meticulous control of blood glucose (BG) would revolutionize diabetes care. Here the authors report the development of a new glucose-responsive insulin delivery system based on the potential interaction between the glucose derivative-modified insulin (Glc-Insulin) and glucose transporters on erythrocytes (or red blood cells, RBCs) membrane. After being conjugated with the glucosamine, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. The delivery vehicle can be further simplified utilizing injectable polymeric nanocarriers coated with RBC membrane and loaded with Glc-Insulin. The described work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness.

引用

页数：7

共 51 条

[1]

American Diabetes Association, 2016, Clin Diabetes, V34, P3, DOI 10.2337/diaclin.34.1.3

[2]

Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells [J].