Cardiovascular and other risk factors for Alzheimer's disease and vascular dementia

被引:83
作者
Meyer, JS
Rauch, GM
Rauch, RA
Haque, A
Crawford, K
机构
[1] VAMC, Cerebral Blood Flow Lab, Houston, TX 77030 USA
[2] VAMC, Serv Radiol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA
[4] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA
来源
VASCULAR FACTORS IN ALZHEIMER'S DISEASE | 2000年 / 903卷
关键词
D O I
10.1111/j.1749-6632.2000.tb06393.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Factors accelerating cerebral degenerative changes represent potentially modifiable risks for cognitive decline, Putative risks accelerating subtle cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT densitometry, perfusions, and cognitive testing among 224 neurologically and cognitively normative aging volunteers. After age 60, cerebral atrophy, ventricular enlargement, polioaraiosis, and leukoaraiosis geometrically increased as perfusions declined. Risks accelerating perfusional decline, cerebral atrophy, polioaraiosis, and leukoaraiosis were: transient ischemic attacks (TIAs), hypertension, smoking, hyperlipidemia, male gender, At age 71.5 +/- 11.9, subtle cognitive decline began, accelerated by TIAs, hypertension, and heart disease. Leukoaraiosis began before cognitive decline. TIAs, hypertension, and hyperlipidemia correlated with vasciular dementias, Excessive cortical perfusional decreases and cerebral atrophy correlated with cognitive decline. Family history of neurodegenerative disease correlated with Alzheimer's disease. We concluded that TIAs, hypertension, hyperlipidemia, smoking, and male gender accelerate cerebral degenerative changes, cognitive decline, and dementia.
引用
收藏
页码:411 / 423
页数:13
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