CD117 (c-kit) expression in human hepatocellular carcinoma

被引：32

作者：

Becker, G. ^{[1
]}

Schmitt-Graeff, A.

Ertelt, V.

Blum, H. E.

Allgaier, H. -P.

机构：

[1] Univ Hosp, Dept Med 2, Freiburg, Germany

[2] Univ Hosp, Inst Pathol, Freiburg, Germany

来源：

CLINICAL ONCOLOGY | 2007年 / 19卷 / 03期

关键词：

CD117; hepatocellular carcinoma; imatinib; tyrosine kinase;

D O I：

10.1016/j.clon.2006.12.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: Although various methods of treatment have been tried, treatment options for advanced hepatoceliular carcinoma (HCC) remain limited. Expression of the platelet-derived growth factor has been shown in HCC, which may derive from hepatic stem cells that express the c-kit proto-oncogene. Because of the promising results of imatinib and the key role played by c-kit in gastrointestinal stromal tumours and other solid tumours, the aim of this study was to determine the prevalence of c-kit (CD117) overexpression in patients with HCC. Materials and methods: A retrospective study of 258 archival specimens of subjects with histologically confirmed HCC was carried out. Expression of the c-kit proto-oncogene was evaluated by immunohistochemistry using rabbit anti-CD117 antibody A4502. Results: The overall percentage of positive immunohistochemical staining of HCCs was 2.3% (6/258). Conclusions: Our results suggest that CD117 is not significantly overexpressed in HCC and there seems to be no role for the use of imatinib.

引用

页码：204 / 208

页数：5

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