Redox Economy in Organic Synthesis

被引:656
作者
Burns, Noah Z. [1 ]
Baran, Phil S. [1 ]
Hoffmann, Reinhard W. [2 ]
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany
关键词
natural products; redox economy; synthesis design; total synthesis; ENANTIOSELECTIVE TOTAL-SYNTHESIS; FORMING TRANSFER HYDROGENATION; ALDEHYDE OXIDATION LEVEL; 1ST TOTAL-SYNTHESIS; ZARAGOZIC ACID-C; ASYMMETRIC-SYNTHESIS; ATOM ECONOMY; EFFICIENT; INHIBITOR; REDUCTION;
D O I
10.1002/anie.200806086
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
"Economy" is referred to as the thrifty and efficient use of material resources, as the principle of "minimum effort to reach a goal." More illuminating is: "the aim to portion ones forces in order to use as little as possible of them to reach a goal." Such statements certainly apply when the goal is to synthesize a complex target molecule. Redox economy then implies the use of as few redox steps as possible in the synthetic conquest of a target compound. While any sort of economy will help to streamline the effort of total synthesis, redox economy addresses a particularly weak area in present-day total synthesis. It is not enough to point out the present deficiencies, rather the purpose of this Review is to serve as a teaching tool for all practitioners of the field by giving and illustrating guidelines to increase redox economy in multistep organic synthesis. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2854 / 2867
页数:14
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