Electron transfer through DNA and peptides

被引：70

作者：

Giese, Bernd ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 18期

关键词：

electron transfer; DNA; peptides; radical ions;

D O I：

10.1016/j.bmc.2006.05.067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrons can migrate through DNA and peptides over very long distances in a multistep hopping process. Stepping stones, which carry the charges for a short time, are the nucleotide bases of DNA or the aromatic side chains of amino acids in peptides. Chemical reactions of these charged intermediates lead to the formation but also to the repair of DNA lesions. In enzymes, long distance electron transfer can activate the binding pocket, and initiates the chemical transformation of the substrate. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：6139 / 6143

页数：5

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