Virus-driven evolution of natural killer cell receptors

被引：48

作者：

Arase, H

Lanier, LL

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 15期

关键词：

NK cell; cytomegalovirus; major histocompatibility complex;

D O I：

10.1016/S1286-4579(02)00033-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells can mount an immediate response against viral infection, secreting cytokines and killing virus-infected cells. However, viruses have devised strategies to avoid immune detection. Here, we discuss NK cell recognition of viruses and propose that viruses may provide the evolutionary pressure causing the diversification of the NK cell receptors. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：1505 / 1512

页数：8

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