Synthesis of para-substituted 3-formyl arylboronic esters

被引:9
作者
Holland, R [1 ]
Spencer, J [1 ]
Deadman, JJ [1 ]
机构
[1] Trigen Ltd, London SW3 6LR, England
来源
SYNTHESIS-STUTTGART | 2002年 / 16期
关键词
boron; nucleophilic aromatic substitutions; cross-coupling; fluorine;
D O I
10.1055/s-2002-35229
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of novel para-substituted amino- and phenoxy-3-formylarylboronic acids is described. These compounds are formed by the hitherto unreported nucleophilic aromatic substitution of fluorine with a range of phenols and amines in the presence of a boronic acid moiety. These reactions proceed in moderate to good yields (37-92%) and provide a useful regioselective synthetic route to trisubstituted arylboronates. These compounds are important both as intermediates in organic synthesis and as end products in their own right.
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页码:2379 / 2382
页数:4
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