TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

被引：206

作者：

Kamer, Angela R. ^{[1
]}

Craig, Ronald G. ^{[1
,2
]}

Pirraglia, Elizabeth ^{[4
]}

Dasanayake, Ananda P. ^{[3
]}

Norman, Robert G. ^{[3
]}

Boylan, Robert J. ^{[2
]}

Nehorayoff, Andrea ^{[1
]}

Glodzik, Lidia ^{[4
]}

Brys, Miroslaw ^{[4
]}

de Leon, Mony J. ^{[4
,5
]}

机构：

[1] NYU, Coll Dent, Dept Periodontol & Implant Dent, New York, NY 10010 USA

[2] NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, New York, NY 10010 USA

[3] NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY 10010 USA

[4] NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

[5] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 216卷 / 1-2期

关键词：

Periodontal antibodies; Alzheimer's disease; TNF-alpha; Inflammation; Diagnosis; Biomarkers; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; TOOTH LOSS; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; SYSTEMIC INFLAMMATION; IGG ANTIBODY; ORAL-HEALTH; INFECTION; RISK; PATHOGENS;

D O I：

10.1016/j.jneuroim.2009.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：92 / 97

页数：6

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