Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea

被引：18

作者：

Daniels, Jan-Peter ^{[1
]}

Kelly, Steven ^{[1
,2
,3
]}

Wickstead, Bill ^{[1
]}

Gull, Keith ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Oxford, Ctr Math Biol, Oxford OX1 3LB, England

[3] Univ Oxford, Dept Biochem, Oxford Ctr Interact Syst Biol, Oxford OX1 3QU, England

来源：

BIOLOGY DIRECT | 2009年 / 4卷

基金：

英国惠康基金;

关键词：

RNA-POLYMERASES; EVOLUTION; PROTEIN;

D O I：

10.1186/1745-6150-4-24

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transcription machineries of Archaea and eukaryotes are similar in many aspects, but little is understood about archaeal chromatin and its role in transcription. Here, we describe the identification in hyperthermophilic Crenarchaeota and a Korarchaeon of an orthologue of the eukaryotic transcription elongation factor Elf1, which has been shown to function in chromatin structure maintenance of actively transcribed templates. Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes.

引用

页数：5

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