In vitro activity of daptomycin against clinical isolates with reduced susceptibilities to linezolid and quinupristin/dalfopristin

被引：30

作者：

Anastasiou, Diane M. ^{[1
]}

Thorne, Grace M. ^{[1
]}

Luperchio, Steven A. ^{[1
]}

Alder, Jeff D. ^{[1
]}

机构：

[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 28卷 / 05期

关键词：

daptomycin; linezolid; quinupristin/dalfopristin; reduced susceptibility;

D O I：

10.1016/j.ijantimicag.2006.07.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An initiative was taken to determine the in vitro activity of daptomycin against 85 Gram-positive isolates with reduced susceptibilities to linezolid and quinupristin/dalfopristin. Daptomycin had potent activity against all strains, with a Staphylococcus spp. minimum inhibitory concentration (MIC) <= 2 mu g/mL and an Enterococcus spp. MIC <= 8 mu g/mL. Resistance to linezolid and quinupristin/dalfopristin appears to be independent of reduced susceptibility to daptomycin. (c) 2006 Published by Elsevier B.V. and the International Society of Chemotherapy.

引用

页码：385 / 388

页数：4

共 17 条

[1] DAPTOMYCIN DISRUPTS MEMBRANE-POTENTIAL IN GROWING STAPHYLOCOCCUS-AUREUS [J].