Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

被引：74

作者：

OketchRabah, HA

Lemmich, E

Dossaji, SF

Theander, TG

Olsen, CE

Cornett, C

Kharazmi, A

Christensen, SB

机构：

[1] ROYAL DANISH SCH PHARM,DEPT MED CHEM,DK-2100 COPENHAGEN O,DENMARK

[2] NATL MUSEUMS KENYA,PHYTOCHEM DEPT,NAIROBI,KENYA

[3] UNIV COPENHAGEN,INST MED MICROBIOL & IMMUNOL,CTR MED PARASITOL,DK-2100 COPENHAGEN N,DENMARK

[4] ROYAL VET & AGR UNIV,DEPT CHEM,DK-1871 FREDERIKSBERG,DENMARK

[5] ROYAL DANISH SCH PHARM,DEPT ANALYT & PHARMACEUT CHEM,DK-2100 COPENHAGEN O,DENMARK

[6] UNIV HOSP 7806,DEPT CLIN MICROBIOL,DK-2200 COPENHAGEN N,DENMARK

[7] UNIV HOSP 7806,CTR MED PARASITOL,DK-2200 COPENHAGEN N,DENMARK

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 05期

关键词：

D O I：

10.1021/np970030o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

引用

页码：458 / 461

页数：4

共 24 条

[21] AN UNUSUAL [2+2] CYCLOADDUCT OF TERPENOID COUMARIN FROM ETHULIA-VERNONIOIDES [J].