MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers

被引：39

作者：

Wang, Xian ^{[2
]}

Lam, Emily K. Y. ^{[1
]}

Zhang, Jianbin ^{[1
]}

Jin, Hongchuan ^{[1
]}

Sung, Joseph J. Y. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Inst Digest Dis, Dept Med & Therapeut, Prince Wales Hosp,Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 387卷 / 02期

关键词：

microRNA; miR-122a; APC; Gastrointestinal cancers; HEPATITIS-C VIRUS; DOWN-REGULATION; MIR-122; APC; EXPRESSION; CATENIN; MIRNAS; GENE; WNT;

D O I：

10.1016/j.bbrc.2009.07.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant regulation of APC/beta-catenin signaling pathway is common in the pathogenesis of colorectal and other cancers. Targets regulated by APC/beta-catenin signaling pathway play crucial roles in cancer development. In the current study, we aimed to illustrate the influence of APC/beta-catenin signaling pathway on expression of microRNAs, one new group of players important to carcinogenesis. Restoration of APC function in colorectal cancer cells led to the deregulation of several cancer-related microRNAs, such as miR-122a which was recognized as the liver-specific microRNA. MiR-122a was down-regulated in gastrointestinal cancer cell lines as well as primary carcinoma tissues. Inhibition of miR-122a could reverse wild-type APC-induced growth inhibition of gastrointestinal cancer cells while miR-122a mimic inhibited cell growth. In summary, we identified some cancer-related microRNAs regulated by APC/beta-catenin signaling pathway. The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：376 / 380

页数：5

共 30 条

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