Advancements in transfection technologies for Plasmodium

被引：32

作者：

Balu, Bharath ^{[1
]}

Adams, John H. ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Sci Biol, Ctr Global Hlth & Infect Dis, Notre Dame, IN 46556 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2007年 / 37卷 / 01期

关键词：

malaria; Plasmodium; gene transfer; transfection; transformation;

D O I：

10.1016/j.ijpara.2006.10.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Malaria is a global problem that affects millions of people annually. A relatively poor understanding of the malaria parasite biology has hindered vaccine and drug development against this disease. Robust methods for genetic analyses in Plasinodium have been lacking due to the difficulties in its genetic manipulation. Introduction of transfection technologies laid the foundation for genetic dissection of Plasmodium and recent years have seen the development of novel tools for genetic manipulation that will help us delineate the intriguing biology of this parasite. This review focuses on such recent advances in transfection technologies for Plasmodium that have improved our ability to carry out more thorough genetic analyses of the biology of the malaria parasite. (c) 2006 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1 / 10

页数：10

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