Analysis of genetic heterogeneity of hepatitis C viruses in Central America reveals a novel genetic lineage

被引：6

作者：

San Román, M ^{[1
]}

Lezama, L

Rojas, E

Colina, R

García, L

Carlos, A

Khan, B

Cristina, J

机构：

[1] Hosp San Juan Dios, Clin Lab, San Jose, Costa Rica

[2] Univ Republica, Fac Ciencias, Ctr Invest Nucl, Dept Tecn Nucl Aplicadas, Montevideo, Uruguay

[3] IAEA, Div Human Hlth, Vienna, Austria

来源：

ARCHIVES OF VIROLOGY | 2002年 / 147卷 / 11期

关键词：

D O I：

10.1007/s00705-002-0869-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) has high genomic variability and at least six different types have been reported. The genotypes distribution is currently unknown among HCV strains circulating in Central America. In order to study the degree of genetic variability of strains isolated in Costa Rica, sequence data obtained from the 5' non coding region from 7 patients from Costa Rica were compared with published sequences from 57 strains of all types. The phylogenetic analysis revealed the existence of type 1 strains of a novel genetic lineage, recently described for some South American countries, and indicates an increasing diversification of HCV.

引用

页码：2239 / 2246

页数：8

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