Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation

被引：105

作者：

Hall, Joshua D. ^{[1
]}

Craven, Robin R. ^{[1
]}

Fuller, James R. ^{[1
]}

Pickles, Raymond J. ^{[1
]}

Kawula, Thomas H. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 02期

关键词：

D O I：

10.1128/IAI.01254-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.

引用

页码：1034 / 1039

页数：6

共 18 条

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