The use of tolerance for transplantation across xenogeneic barriers

被引：21

作者：

Greenstein, JL

Sachs, DH

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02129

[2] MASSACHUSETTS GEN HOSP,TRANSPLANTAT BIOL RES CTR,BOSTON,MA 02129

来源：

NATURE BIOTECHNOLOGY | 1997年 / 15卷 / 03期

关键词：

xenotransplantation; immune tolerance; miniature swine;

D O I：

10.1038/nbt0397-235

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The success of human organ transplantation as a clinical treatment has created a conundrum for the transplant community. It has caused a shortage of human donor organs and uncovered problems of chronic immunosuppression in those lucky enough to receive organ transplants due to their use of chronic immunosuppressive drugs. Our aim is to attempt to approach both issues by establishing specific transplantation tolerance to pig organ grafts.

引用

页码：235 / 238

页数：4

共 57 条

[1]

Alexandre G.P.J., 1989, XENOGRAFT, V25, P259

[2]

ALEXANDRE GPJ, 1987, TRANSPLANT P, V19, P4538

[3] Delayed xenograft rejection [J].