A role for adenosine in the regulation of long-term depression in the adult rat hippocampus in vitro

被引：24

作者：

Kemp, N ^{[1
]}

Bashir, ZI ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH MED SCI,DEPT ANAT,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1997年 / 225卷 / 03期

基金：

英国惠康基金;

关键词：

synaptic plasticity; CA1; hippocampus; long-term depression; adenosine; 1,3-dipropyl-8-cyclopentylxanthine;

D O I：

10.1016/S0304-3940(97)00221-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe how endogenous adenosine can prevent the induction of homosynaptic long-term depression (LTD) in the CA1 region of slices of adult rat hippocampus. Neither of two consecutive periods of prolonged low frequency stimulation (LFS; 1 Hz, 900 stimuli) of the Schaffer collateral-commissural fibres resulted in the induction of LTD in the CA1 region of hippocampal slices from adult (8-30 week) animals. However, in the presence of adenosine deaminase or the selective adenosine A(1) receptor antagonist, 1,3-dipropyl-8-cyclopentyl-xanthine (DPCPX), LTD was induced by each of the first and second of two periods of LFS. The first period of LFS did not, but the second period of LFS did, induce LTD in the presence of DPCPX and the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5). The present results show that A(1) receptor activation by endogenous adenosine can prevent the induction of LTD in the adult hippocampus. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：189 / 192

页数：4

共 27 条

[1] AN INVESTIGATION OF DEPOTENTIATION OF LONG-TERM POTENTIATION IN THE CA1 REGION OF THE HIPPOCAMPUS [J].

BASHIR, ZI ;

COLLINGRIDGE, GL .

EXPERIMENTAL BRAIN RESEARCH, 1994, 100 (03) :437-443

[2] POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION [J].

BOLSHAKOV, VY ;

SIEGELBAUM, SA .

SCIENCE, 1994, 264 (5162) :1148-1152

[3] REGULATION OF HIPPOCAMPAL TRANSMITTER RELEASE DURING DEVELOPMENT AND LONG-TERM POTENTIATION [J].

BOLSHAKOV, VY ;

SIEGELBAUM, SA .

SCIENCE, 1995, 269 (5231) :1730-1734

[4] Ca2+ signaling requirements for long-term depression in the hippocampus [J].

Cummings, JA ;

Mulkey, RM ;

Nicoll, RA ;

Malenka, RC .

NEURON, 1996, 16 (04) :825-833

[5] ADENOSINE INHIBITS THE NMDA RECEPTOR-MEDIATED EXCITATORY POSTSYNAPTIC POTENTIAL IN THE HIPPOCAMPUS [J].

DEMENDONCA, A ;

RIBEIRO, JA .

BRAIN RESEARCH, 1993, 606 (02) :351-356

[6]

DEMENDONCA A, 1996, IN PRESS NEUROPHARMA

[7] HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF HIPPOCAMPUS AND EFFECTS OF N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE [J].

DUDEK, SM ;

BEAR, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4363-4367

[8]

DUDEK SM, 1993, J NEUROSCI, V13, P2910

[9] ALKYLXANTHINES ELEVATE HIPPOCAMPAL EXCITABILITY - EVIDENCE FOR A ROLE OF ENDOGENOUS ADENOSINE [J].

DUNWIDDIE, TV ;

HOFFER, BJ ;

FREDHOLM, BB .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1981, 316 (04) :326-330

[10] HOW DOES ADENOSINE INHIBIT TRANSMITTER RELEASE [J].

FREDHOLM, BB ;

DUNWIDDIE, TV .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (04) :130-134

← 1 2 3 →