Dopamine receptor-coupling defect in hypertension

被引:39
作者
Jose, PA [1 ]
Eisner, GM [1 ]
Felder, RA [1 ]
机构
[1] Georgetown Univ, Med Ctr, Washington, DC 20007 USA
关键词
D O I
10.1007/s11906-002-0013-6
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Dopamine synthesized in non-neural tissues, eg, renal proximal tubule, functions in an autocrine or paracrine manner. The effects of cloparnine are transduced by two classes of receptors (D-1- and D-2-like) that belong to the superfamily of G protein-coupled receptors. In genetic hypertension, the D-1 receptor, a member of the D-1-like receptor family, is uncoupled from its G protein complex, resulting in a decreased ability to regulate renal sodium transport. The impaired D-1 receptor/G protein coupling in renal proximal tubules in genetic hypertension is secondary to abnormal phosphorylation and desensitization of the D-1 receptor caused by activating single nucleotide polymorphisms of a G protein-coupled receptor kinase, GRK type 4.
引用
收藏
页码:237 / 244
页数:8
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