Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2)

被引：34

作者：

D'Alia, Davide ^{[1
]}

Nieselt, Kay ^{[2
]}

Steigele, Stephan ^{[2
]}

Mueller, Jonas ^{[2
]}

Verburg, Ilse ^{[1
]}

Takano, Eriko ^{[1
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Microbial Physiol, NL-9751 NN Haren, Netherlands

[2] Univ Tubingen, Ctr Bioinformat Tubingen, Dept Informat & Cognit Sci, D-72076 Tubingen, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 04期

关键词：

HUMAN GENOME; MYCOBACTERIUM-TUBERCULOSIS; STRUCTURED RNAS; VIBRIO-HARVEYI; IDENTIFICATION; GENE; PREDICTION; ENCODES; ABSB;

D O I：

10.1128/JB.01374-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants.

引用

页码：1160 / 1164

页数：5

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