Non-coding RNAs: Lost in translation?

被引：114

作者：

Costa, Fabricio F.

机构：

[1] Childrens Mem Res Ctr, Canc Biol & Epigenom Program, Chicago, IL 60614 USA

[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60614 USA

来源：

GENE | 2007年 / 386卷 / 1-2期

关键词：

non-coding RNAs; RNome; transcriptome analyses; transcriptional noise; pathological conditions; RNA function;

D O I：

10.1016/j.gene.2006.09.028

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the last ten years, several RNAs with no protein-coding potential have been accumulating in RNA databases and are in need of further molecular characterization. At the same time, examples of non-coding RNAs (ncRNAs) such as microRNAs, small RNAs, small interfering RNAs (SiRNAs) and medium/large RNAs with various functions have been described in the literature. Recent evidence points to a widespread role of these molecules in eukaryotic cells, suggesting that the majority of the new ncRNA examples might have specific functions. The aim of this review is to describe several new functional ncRNAs that have been recently identified and characterized, providing some clues that these molecules might not be produced by chance or as by-products of transcription as has been speculated. (c) 2006 Elsevier B.V. All rights reserved.

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页码：1 / 10

页数：10

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