Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

被引:97
作者
Barlow, Christy A. [1 ]
Laishram, Rakesh S. [1 ]
Anderson, Richard A. [1 ]
机构
[1] Univ Wisconsin, Sch Med, Dept Pharmacol, Madison, WI 53706 USA
基金
美国国家卫生研究院;
关键词
MESSENGER-RNA EXPORT; PHOSPHATIDYLINOSITOL-PHOSPHATE KINASE; ACTIN-RELATED PROTEINS; INOSITOL POLYPHOSPHATES; PHOSPHOLIPASE-C; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; CHROMATIN PHOSPHOLIPIDS; TRANSCRIPTIONAL CONTROL; DIACYLGLYCEROL KINASE;
D O I
10.1016/j.tcb.2009.09.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the cytosolic phosphoinositide signaling pathway, nuclear phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) is at the center of the pathway and acts both as a messenger and as a precursor for many additional messengers. Here, recent advances in the understanding of nuclear phosphoinositide signaling and its functions are reviewed with an emphasis on PI4,5P(2) and its role in gene expression. The compartmentalization of nuclear phosphoinositide phosphates (PIPn) remains a mystery, but emerging evidence suggests that phosphoinositides occupy several functionally distinct compartments.
引用
收藏
页码:25 / 35
页数:11
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