Long-term survival effects of GDNF on neonatal rat facial motoneurons after axotomy

被引：37

作者：

Matheson, CR ^{[1
]}

Wang, J ^{[1
]}

Collins, FD ^{[1
]}

Yan, Q ^{[1
]}

机构：

[1] AMGEN INC,DEPT NEUROBIOL,THOUSAND OAKS,CA 91320

来源：

NEUROREPORT | 1997年 / 8卷 / 07期

关键词：

cell death; facial nerve axotomy; glial cell line-derived neurotrophic factor; neurotrophic factor; neurotrophin;

D O I：

10.1097/00001756-199705060-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLIAL cell-line derived neurotrophic factor (GDNF) has survival promoting effects on axotomized neonatal motoneurons. We examined how long it could sustain motoneurons after postnatal day 0 (PND) facial nerve axotomy. GDNF, or cytochrome c as a negative control, were locally administered by Gelfoam implants at the time of axotomy and some were re-implanted on PND 14. The surviving motoneurons were quantified on PND 14 and 28. GDNF completely rescued lesioned motoneurons from axotomy-induced cell death at 14 days and was still effective (about 40%) at PND 28. GDNF also prevented axotomy-induced atrophy at both PND 14 and 28, indicating that the neurotrophic effects of GDNF on neonatal motoneurons are long-term.

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页码：1739 / 1742

页数：4

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