Long-term survival effects of GDNF on neonatal rat facial motoneurons after axotomy

被引：37

作者：

Matheson, CR ^{[1
]}

Wang, J ^{[1
]}

Collins, FD ^{[1
]}

Yan, Q ^{[1
]}

机构：

[1] AMGEN INC,DEPT NEUROBIOL,THOUSAND OAKS,CA 91320

来源：

NEUROREPORT | 1997年 / 8卷 / 07期

关键词：

cell death; facial nerve axotomy; glial cell line-derived neurotrophic factor; neurotrophic factor; neurotrophin;

D O I：

10.1097/00001756-199705060-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLIAL cell-line derived neurotrophic factor (GDNF) has survival promoting effects on axotomized neonatal motoneurons. We examined how long it could sustain motoneurons after postnatal day 0 (PND) facial nerve axotomy. GDNF, or cytochrome c as a negative control, were locally administered by Gelfoam implants at the time of axotomy and some were re-implanted on PND 14. The surviving motoneurons were quantified on PND 14 and 28. GDNF completely rescued lesioned motoneurons from axotomy-induced cell death at 14 days and was still effective (about 40%) at PND 28. GDNF also prevented axotomy-induced atrophy at both PND 14 and 28, indicating that the neurotrophic effects of GDNF on neonatal motoneurons are long-term.

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收藏

页码：1739 / 1742

页数：4

相关论文

共 21 条

[11] DEVELOPING MOTOR-NEURONS RESCUED FROM PROGRAMMED AND AXOTOMY-INDUCED CELL-DEATH BY GDNF [J].

OPPENHEIM, RW ;

HOUENOU, LJ ;

JOHNSON, JE ;

LIN, LFH ;

LI, LX ;

LO, AC ;

NEWSOME, AL ;

PREVETTE, DM ;

WANG, SW .

NATURE, 1995, 373 (6512) :344-346

[12] Renal agenesis and the absence of enteric neurons in mice lacking GDNF [J].

Sanchez, MP ;

SilosSantiago, I ;

Frisen, J ;

He, B ;

Lira, SA ;

Barbacid, M .

NATURE, 1996, 382 (6586) :70-73

[13] BRAIN-DERIVED NEUROTROPHIC FACTOR PREVENTS THE DEATH OF MOTONEURONS IN NEWBORN RATS AFTER NERVE-SECTION [J].

SENDTNER, M ;

HOLTMANN, B ;

KOLBECK, R ;

THOENEN, H ;

BARDE, YA .

NATURE, 1992, 360 (6406) :757-759

[14]

TZUZUKI T, 1995, ONCOGENE, V10, P191

[15] BDNF-MEDIATED RESCUE OF AXOTOMIZED MOTOR-NEURONS DECREASES WITH INCREASING DOSE [J].

VEJSADA, R ;

SAGOT, Y ;

KATO, AC .

NEUROREPORT, 1994, 5 (15) :1889-1892

[16] QUANTITATIVE COMPARISON OF THE TRANSIENT RESCUE EFFECTS OF NEUROTROPHIC FACTORS ON AXOTOMIZED MOTONEURONS IN-VIVO [J].

VEJSADA, R ;

SAGOT, Y ;

KATO, AC .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (01) :108-115

[17] BRAIN-DERIVED NEUROTROPHIC FACTOR RESCUES SPINAL MOTOR NEURONS FROM AXOTOMY-INDUCED CELL-DEATH [J].

YAN, Q ;

ELLIOTT, J ;

SNIDER, WD .

NATURE, 1992, 360 (6406) :753-755

[18] IN-VIVO NEUROTROPHIC EFFECTS OF GDNF ON NEONATAL AND ADULT FACIAL MOTOR-NEURONS [J].

YAN, Q ;

MATHESON, C ;

LOPEZ, OT .

NATURE, 1995, 373 (6512) :341-344

[19] INFLUENCES OF NEUROTROPHINS ON MAMMALIAN MOTONEURONS IN-VIVO [J].

YAN, Q ;

ELLIOTT, JL ;

MATHESON, C ;

SUN, JL ;

ZHANG, L ;

MU, XJ ;

REX, KL ;

SNIDER, WD .

JOURNAL OF NEUROBIOLOGY, 1993, 24 (12) :1555-1577

[20] DISTRIBUTION OF INTRACEREBRAL VENTRICULARLY ADMINISTERED NEUROTROPHINS IN RAT-BRAIN AND ITS CORRELATION WITH TRK RECEPTOR EXPRESSION [J].

YAN, Q ;

MATHESON, C ;

SUN, J ;

RADEKE, MJ ;

FEINSTEIN, SC ;

MILLER, JA .

EXPERIMENTAL NEUROLOGY, 1994, 127 (01) :23-36