Serum levels of soluble form of Fas molecule in patients with congestive heart failure

被引：67

作者：

Okuyama, M

Yamaguchi, S

Nozaki, N

Yamaoka, M

Shirakabe, M

Tomoike, H

机构：

[1] First Dept. of Internal Medicine, Yamagata University Medical School, Yamagata

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 12期

关键词：

D O I：

10.1016/S0002-9149(97)00228-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Compared with soluble Fas molecule (sFas, an inhibitor of Fas-mediated apoptosis) in normal volunteers, the serum level of sFas significantly increased by 41% in New York Heart Association (NYHA) class III (p < 0.05) and by 97% in NYHA class IV patients with congestive heart failure (p < 0.001). Furthermore, sFas showed correlations with soluble forms of TNF receptor-p55 (RI) and -p75 (RII) (r = 0.68 and r = 0.56) which inhibit activities of TNF alpha.

引用

收藏

页码：1698 / &

页数：6

相关论文

共 25 条

[1] PROTECTION FROM FAS-MEDIATED APOPTOSIS BY A SOLUBLE FORM OF THE FAS MOLECULE [J].

CHENG, JH ;

ZHOU, T ;

LIU, CD ;

SHAPIRO, JP ;

BRAUER, MJ ;

KIEFER, MC ;

BARR, PJ ;

MOUNTZ, JD .

SCIENCE, 1994, 263 (5154) :1759-1762

[2] STRETCH-INDUCED PROGRAMMED MYOCYTE CELL-DEATH [J].

CHENG, W ;

LI, BS ;

KAJSTURA, J ;

LI, P ;

WOLIN, MS ;

SONNENBLICK, EH ;

HINTZE, TH ;

OLIVETTI, G ;

ANVERSA, P .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2247-2259

[3] FAS AND TUMOR-NECROSIS-FACTOR RECEPTOR-MEDIATED CELL-DEATH - SIMILARITIES AND DISTINCTIONS [J].

CLEMENT, MV ;

STAMENKOVIC, I .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (02) :557-567

[4]

ENGELMANN H, 1989, J BIOL CHEM, V264, P11974

[5]

ENGELMANN H, 1990, J BIOL CHEM, V265, P1531

[6] TUMOR-NECROSIS-FACTOR SOLUBLE RECEPTORS IN PATIENTS WITH VARIOUS DEGREES OF CONGESTIVE-HEART-FAILURE [J].

FERRARI, R ;

BACHETTI, T ;

CONFORTINI, R ;

OPASICH, C ;

FEBO, O ;

CORTI, A ;

CASSANI, G ;

VISIOLI, O .

CIRCULATION, 1995, 92 (06) :1479-1486

[7]

GIRARDIN E, 1992, IMMUNOLOGY, V76, P20

[8] THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS [J].

ITOH, N ;

YONEHARA, S ;

ISHII, A ;

YONEHARA, M ;

MIZUSHIMA, S ;

SAMESHIMA, M ;

HASE, A ;

SETO, Y ;

NAGATA, S .

CELL, 1991, 66 (02) :233-243

[9] ELEVATED CIRCULATING LEVELS OF TUMOR-NECROSIS-FACTOR IN SEVERE CHRONIC HEART-FAILURE [J].

LEVINE, B ;

KALMAN, J ;

MAYER, L ;

FILLIT, HM ;

PACKER, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (04) :236-241

[10] Evidence of apoptosis in arrhythmogenic right ventricular dysplasia [J].

Mallat, Z ;

Tedgui, A ;

Fontaliran, F ;

Frank, R ;

Durigon, M ;

Fontaine, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (16) :1190-1196